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Semax via BDNF-TrkB survival signalling

Song, Z., Xiaoli, A

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Together with existing docking and pharmacological studies, these findings support a general pharmacophore in which a conserved basic center, C15/C20 hydrophobic substituents, and configuration-dependent orientation of the indole/oxindole core jointly dictate MOR affinity, subtype selectivity, and potentially signaling bias (Figure 11)