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Inefficiency of the phagocytosis process leads to the formation of residual lipid-protein granules that cannot be degraded, known as lipofuscin, and generation of ROS occurs from the constant exposure of lipofuscin to light and oxygen tension 1

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Pedre et al., 2021)

The substances were combined and appropriately diluted using methanol for HPTLC and mobile phase for HPLC/DAD, respectively

Although these typical changes are not necessarily characteristic of ME/CFS, another autoimmune mechanism may exist in ME/CFS that affects the autonomic control of blood vessel tone and flow autoregulation