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Nevertheless, as the unnecessary side effects of intravenous NGF on the peripheral nerve are limited by its low stability, short half-life, and high cost (89, 90), it is not encouraged to try exogenous NGF in humans (91)

doi: 10.18632/oncotarget.316

This heterogeneity can result from differences in the type, dose, intensity, and temporal sequence of antigenic stimuli to which each person is exposed

Plikus MV, Wang X, Sinha S, Forte E, Thompson SM, Herzog EL, et al