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2012 Mar 31;379(9822):1256-68

10.1016/j.jmb.2016.05.021 71 ParkS.RancourD

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A drawback of the latter is that repeated treatments are likely to lead to cancer cells developing resistance to the drug, resulting in recurrence, development of metastases, and poor prognosis for patients
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Becker SA, Feist AM, Mo ML, Hannum G, Palsson B, Herrgard MJ
