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[DOI] [PMC free article] [PubMed] [Google Scholar] 34.Bakulin I, Pasechnikov V, Varlamicheva A, Sannikova I

consider discontinuation of valproate therapy (5.6, 5.9, 5.10) Hypothermia: Hypothermia has been reported during valproate therapy with occur in patients using concomitant topiramate (5.11) Drug Reaction with Eosinophilia and Systemic Symptoms (DRESS)/Multiorgan Hypersensitivity Reactions, serious dermatologic reactions, and angioedema: Discontinue Depakote unless an alternate etiology is established (4, 5.12, 5.13, 5.14) Adverse Reactions/Side Effects Most common adverse reactions (reported 15% for any indication) are abdominal pain, alopecia, asthenia, diarrhea, diplopia, dizziness, headache, infection, insomnia, nausea, somnolence, thrombocytopenia, tremor, vomiting (6.1, 6.2, 6.3)

Moreover, in overdose, CCAs may inhibit calcium channels outside the cardiovascular system

Proper use of supplements that ensure proper hormonal management prevents the above problems

Lim J, Li J, Feng X, Feng L, Xiao X, Zhou M, Yang H, Xu Z (2024) Predicting TCM patterns in PCOS patients: an exploration of feature selection methods and multi-label machine learning models

New hepatic fat activates PPARalpha to maintain glucose, lipid, and cholesterol homeostasis