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The TCA cycle of M2 macrophages has no metabolic flux escape whereas M1 macrophages (treated with LPS) have two points of substrate flux deviation, one occurring at the isocitrate dehydrogenase step reaction and another one at post succinate formation
Zhao et al., 2008
The novelty of this review lies in its comprehensive approach that brings together biomarkers of oxidative stress, inflammation, and genetic/epigenetic regulation within a clinically oriented multi-omics and an artificial intelligence (AI)-guided framework
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Intervention trials are limited, and the findings of available trials are inconsistent
