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Are histological changes that persist after the protocol ends, provided the injury or stressor that caused the original damage is no longer present

Yes, and they often benefit from them
Supplement Gaps Oral vitamins lose potency through digestion

The lack of alterations in gene expression could be due to a delayed response, as suggested by the authors, intimating that gene expression does not immediately change following a difference in DNA methylation

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Falls on outstretched hands commonly cause these injuries, though repetitive strain can also weaken ligaments over time