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It is suggested that phosphorylation impacts on the allosteric regulation of MTHFR via altering the equilibrium of active and inactive states of the enzyme, favoring the inactive state which SAM preferentially binds 21

[DOI] [PMC free article] [PubMed] [Google Scholar] Tang L

Our data also paves the way for LH GABAergic neurons, among other cell types (perhaps glutamatergic), in the Lateral Hypothalamus to be a potential pharmacological target for developing new appetite suppressants to treat obesity