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As with any emerging pharmacological agent, the establishment of a safe and effective dosage for clinical use necessitates thorough and rigorous clinical trials

[11] found that NNMT expression levels are elevated in WAT and the liver of the T2D mice and that NNMT knockdown improves the glucose tolerance and insulin sensitivity in the T2D mice

Due to the limited data, it should be avoided by anyone who is pregnant, breastfeeding, or undergoing active cancer treatment