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Guo, J., Zhang, R., Zhao, Y

Key Points Intervertebral disc (IVD) degeneration is frequently associated with low back and neck pain The avascularity of the IVD is an obstacle to intrinsic repair by exogenous cells Tissue-specific progenitor cells have been identified in the IVD, and these cells could be targeted to promote intrinsic repair Supplementation of functional cells from exogenous sources has IVD-regenerative effects in basic and preclinical studies A growing number of clinical trials are assessing the effects of cell therapy for IVD disease Despite promising results of cell therapy for IVD disease in preclinical studies, various obstacles remain to define its efficacy and target indications Abstract Intervertebral disc (IVD) degeneration is frequently associated with low back and neck pain, which accounts for disability worldwide

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This trend is mirrored in other regions, including Europe and Asia-Pacific, where rising obesity rates among adults are contributing to the markets expansion

Insulin resistance is associated with increased serum concentration of IGF-binding protein-related protein 1 (IGFBP-rP1/MAC25)

Mothers in this study were not undernourished, consumed animal protein, and had adequate vitamin B 12 intake during pregnancy and postpartum according to responses given to dietary questionnaires