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The catalytic mechanism of two sites involved in GSTs is as follows: (1) GSH binds to the G site to form the strong nucleophilic thiolate anion, (2) the electrophilic substrate bound to the H site reacts with the thiolate anion of GSH to form the GSH conjugate, which will be released via the C-terminus [34]

J Investig Dermatol 137:22482250

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