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Xenobiotics with nucleophilic carbon atoms such as phenylbutazone form C-glucuronides
However, it is now clear that this popular approach ignores the root causes of NAD+ decline meaning supplementation with precursors alone such as NR or NMN do not offer a long-term efficacious solution for NAD+ restoration
[PubMed] [Google Scholar][99] Avitabile T, Longo A, Reibaldi A
doi: 10.1097/00045391-200007020-00010
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