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Species-specific differences in metabolic pathways, immune cell composition, and tumor microenvironmental dynamics limit the extent to which findings in mice can be directly extrapolated to patients

The use of human embryonic stem cells, derived from early-stage embryos, is subject to strict regulatory guidelines due to ethical considerations

It is also involved in cholesterol levels.[ref] Genetic variants in the methylation pathway, including MTHFR, are strongly linked to high homocysteine levels and heart disease in many studies

However, the efficacy of TACE in achieving tumor shrinkage has sometimes fallen short of expectations, necessitating the addition of conventional measures such as continuous dextrose infusion [42]

Pagani, M

van den Berg et al., 2009