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Thus, GSH and ATF4 levels in CML cells are the markers to indicate JMF4073 sensitivity and determine the selection of GSH blocker for the combination with JMF4073 in therapy

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[DOI] [PubMed] [Google Scholar] Wick S

GLUD1: Glutamate dehydrogenase 1 GMP: Guanosine monophosphate GOT2: Glutamic oxaloacetic transaminase 2 GPNA: L--Glutamyl-p-nitroanilide GPT2: Glutamic pyruvic transaminase 2 GS: Glutamine synthetase IDH: Isocitrate dehydrogenase ISR: Integrated stress response MM: Multiple myeloma mTORC1: mTOR complex 1 mTORC2: mTOR complex 2 NDRG2: N-Myc downstream regulated gene 2 NEAA: Nonessential amino acid PC: Plasma cell PD-1: Programmed cell death protein 1 PDK1: Pyruvate dehydrogenase kinase 1 PRPP: Phosphoribosylpyrophosphate PSAT1: Phosphoserine aminotransferase 1 ROS: Reactive oxygen species SHMT: Serine hydroxymethyltransferase SLC1A5: Solute carrier family 1 neutral amino acid transporter member 5 TCA: Tricarboxylic acid References Hanahan D, Weinberg RA

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