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Furthermore, the consumption of omega-3 PUFA may increase the expression of endothelial nitric oxide synthase and the production of NO

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It alleviated the intensity of hypoxia-induced nerve cell damage, improved interhemispheric transmission, and increased glucose metabolism in the rat brain [80]

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ApoE in dysregulation of lipid metabolism As a major lipid transporter in the brain, apoE has been shown to mediate lipid and cholesterol metabolism in an isoform-dependent manner [131]

Testosterone deprivation accelerates cardiac dysfunction in obese male rats