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Funding The experimental work cited in this study was supported by the VEGA grants No

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Practically, the full protein-coding sequences of sll1545 and slr0236 were independently replaced by a transcription-terminator-less antibiotic-resistance gene Km r or Sm r /Sp r for selection, while preserving 300 bp of the sll1545 and slr0236 flanking DNA regions for homologous recombination mediating targeted gene replacement upon transformation to Synechocystis ( E

While it is available as a licensed prescription medicine for confirmed carnitine deficiency, over-the-counter supplements occupy a very different regulatory space

Despite advances, challenges remain in translating these technologies clinically, including ensuring biocompatibility, scalable manufacturing, and patient acceptance