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Non-enzymatic production of ROS in melanocytes mainly occurs during normal cellular processes, such as mitochondrial respiration, where the electron transport chain plays a crucial role

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The products generated in this reaction are peroxynitrite (ONOO ) which results from the formation of hydroxyl radical (OH), which is greatly reactive and results in the alteration of cellular functioning and cause dysfunction of endothelial cells, and 3) Massive generation of O 2 may result in proliferation and apoptotic death of epithelial cells (Pacher et al., 2007