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The reduced form of glutathione plays a fundamental role in the defense of the organism against damage caused by oxidative stress [76]

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Clinical efficacy of cabozantinib plus nivolumab (CaboNivo) and CaboNivo plus ipilimumab (CaboNivoIpi) in patients (pts) with chemotherapy-refractory metastatic urothelial carcinoma (mUC) either nave (n) or refractory (r) to checkpoint inhibitor (CPI)

PRDX1 stabilizes NFE2L2 by inhibiting cullin 3 (CUL3)-mediated ubiquitination, thereby promoting transcription of genes involved in GSH synthesis ( GCLC , GCLM ) and cystine import ( SLC7A11 ) 113

MOTS-C is part of a small group of mitochondrial-derived peptides linked to longer lifespan in animal studies