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Alterations in both pathways enhance oxidative stress and increase APAP toxicity

When vitamin C donates electrons to neutralize free radicals, glutathione can restore vitamin C to its active form, and vitamin C can do the same for glutathione, creating a continuous antioxidant cycle

The investigators reported concentration-dependent reductions in fat mass and adipose-tissue NNMT activity without significant changes in lean mass or food intake

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Densitometric analysis was used to determine differences in protein expression