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Researchers typically monitor cortisol and prolactin levels during protocols to ensure hormonal balance and accurate interpretation of GH-related outcomes

Curcumin also shows binding potential to matrix metalloproteinase 3 (MMP-3), a protease whose expression and activity are elevated in chronic inflammatory diseases, including RA (33)

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Additionally, disruption of the bloodbrain barrier (BBB) occurs through endothelial injury, tight junction breakdown, and matrix metalloproteinase activation, which increases vascular permeability and contributes to cerebral edema and secondary injury (28)

However, it is possible that the observed differences in tolerance are attributable to the positional influence of distinct transgenic lines