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Segal LN, Clemente JC, Tsay JC, Koralov SB, Keller BC, Wu BG, et al

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However, the mean age of their subjects was a relatively young 38.5 years and most of the studies involved short-term follow-up

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In contrast, we observed a significant reduction in 16 metabolites in LC patients compared to those with acute COVID-19 disease ( Supplementary Figure 12 )

Species-specific differences in metabolic pathways, immune cell composition, and tumor microenvironmental dynamics limit the extent to which findings in mice can be directly extrapolated to patients