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In this narrative review the authors address the putative reno-protective effects of DEX and summarise the results from clinical and animal studies addressing the use of DEX for the prevention of AKI

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In this study, we show in a preclinical therapeutic trial that inducible deletion of EGFR in myeloid cells of GEMMs with established CRC results in tumor reduction, indicating that the therapeutic efficacy of EGFR inhibition largely relies on its action on myeloid cells

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