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However, given that some studies report limited or no effects, additional long-term clinical trials are warranted to validate the reproducibility and degree of presented benefits

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The most useful nuance for readers comparing headlines: REDEFINE 1's 20.4% number is the treatment-policy estimand (closer to intention-to-treat what happens regardless of whether participants stayed on treatment)

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Understand the Risks: Medical testing and the appropriate dosage can mitigate the risks associated with antioxidant use