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First, the plasma membrane of the cell invaginates, forming a pocket around the target cargo [70]

Published 2020 Dec 14

Effect of aldose reductase inhibitors on naphthalene cataract formation in the rat

To test this, we synthesized two bromodomain and extraterminal (BET) ligands and two poly(ADP-ribose) polymerase (PARP1/2) ligands harboring JS-1 at previously established exit vector positions, none of which succeeded in degrading their targets (Extended Data Fig

Hooda, Z, Ries, S, Fabian, T, Freeman, KA, Hofstetter, WL, Hudson, J, Mehran, RJ, Rajaram, R, Rice, DC, Swisher, SG, Vaporciyan, AA, Walsh, GL, Mitchell, KG, Zaku, B, Antonoff, MB