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One of the reasons why acute COVID has killed more men than women could lie in the fact that the IFN- response to a viral infection is stronger in women than in men (110, 111)

Role of pannexin-1-P2X7R signaling on cell death and pro-inflammatory mediator expression induced by Clostridioides difficile toxins in enteric glia
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doi: 10.4110/in.2018.18.e27 117 FanYDingYLiYZhangDYuMZhouWFet al
D., Dolotov, O
