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As of this writing, CagriSema has an NDA filed with the FDA as of late 2025, with a review expected sometime in 2026

L.BottaryR.SchoerningL.BaerL.GonencA.Eric JensenJ.et al (2020)

hospitalization required Maintenance of Remission: Immunomodulators (azathioprine, 6-MP, methotrexate) for steroid-dependent or frequently-relapsing disease Biologic monotherapy or combination therapy (biologic + immunomodulator) for moderate-to-severe disease Step-up or top-down approach based on disease severity, patient risk factors, and prior therapy Biologic Therapy Targets: TNF-: Infliximab (IV), adalimumab (SC), certolizumab pegol (SC) IL-12/23: Ustekinumab (IV induction, SC maintenance) Integrin: Vedolizumab (IV) IL-23: Risankizumab (IV induction, SC maintenance) JAK inhibition: Upadacitinib (oral) Surgical Management Surgery is indicated in approximately 7080% of patients with Crohns disease over their lifetime, per StatPearls

No entanto, especialistas fazem um alerta: apesar das promessas, muitos dos benefcios atribudos aos peptdeos no tm nenhuma comprovao cientfica e grande parte dessas substncias no possui aprovao regulatria para uso clnico

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Lund J, Winter G, Jones PT, Pound JD, Tanaka T, Walker MR, et al