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The results suggest that secondary pathways may be involved in energy homeostasis, which may be capable of maintaining fat reserve in lean mice by overriding the ADRB3 pathway

100.Bhm M, Luger T

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doi.org/10.3390/molecules191119066 Vasireddi, N., et al

Together, our work shows that tirzepatide produces an increase in all three major islet hormones, displaying functional activity at both incretin receptors in human islets

An extended beneficial effect was also apparent one week later, indicating rescue from ischemic colitis