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Effect of intraventricular injection of 1-methyl-4-phenylpyridinium: protection by acetyl-L-carnitine Hum Exp Toxicol 1995

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461 These neurons also demonstrate increased spontaneous activity independent of ascending afferent input and possess enlarged receptive fields, suggesting that thalamic neurons function as central generators or amplifiers of pain in DPN

Pertanto in questi soggetti la glicemia deve essere controllata regolarmente per poter tempestivamente provvedere, se necessario, allaggiustamento della terapia ipoglicemizzante (vedere paragrafo 4.4)