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proposed ERGO can be used as a therapeutic drug to reduce the severity and mortality of COVID-19, especially in the elderly and people with potential health conditions [19]

The tumor-specificity, retention and BBB-permeability properties of this group of NIRF agents provides a unique platform for their use as a small-molecule drug-carrier system

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Despite the fact it is rarely found in tumors, however, MRP2 in normal cells may impact drug sensitivity because it can influence the distribution and elimination (and hence pharmacokinetics) of some anticancer drugs and their metabolites (see Fig

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