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Guarana Extract comes from the seeds of the caffeine-containing Paullinia cupana plant, native to the South American Amazon Basin

Changes in phosphatidylcholine metabolism are part of an adaptive program activated in response to stress conditions that contribute to cancer therapy resistance and open therapeutic opportunities for treating drug-resistant cancers

Mechanistically, the combination treatment appears to promote the expression of inducible nitric oxide synthase (iNOS) in cardiomyocytes, which in turn alters the misfolded protein response cascade in a cardiomyocyte-intrinsic manner

Intriguingly, the RNAseq analysis revealed an upregulation of both the integrated stress response (ISR) and the mitochondrial unfolded protein response (UPR mt ) genes (Figs

They are also less round and have a higher aspect ratio, a key morphologic parameter indicating the ratio between the length of the major axis and the length of the minor axis (Fig

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