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Dattola, A., et al

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Recent studies are shedding light on the roles that alteration in the TCA cycle enzymes can play in oxphos dependence and in turn, therapy resistance in cancers

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The addition of phenformin, a Complex I inhibitor, caused the oxphos reliant cells to switch to a glycolysis signature, highlighting the plastic nature of the oxphos reliant cells

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However, current treatments for vitiligo remain suboptimal, which may not be equally effective in all vitiligo patients, and it would be inconvenient for patients to visit clinics for phototherapy

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