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Upon APAP treatment, the toxic APAP metabolite N-acetyl-p-benzoquinone imine (NAPQI) depletes glutathione, leading to lipid peroxidation and ferroptotic hepatocyte death 21

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[DOI] [PMC free article] [PubMed] [Google Scholar] 72.Deo S.H., Holwerda S.W., Keller D.M., Fadel P.J

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Furthermore, the relevance of NQOs is based on their capacity to mitigate the noxious effect of several toxins and prooxidants [155]