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CAFFEINE Caffeine is probably the most widely used supplement for exercise performance

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Madhusmita Sahoo JKB, Bhaskar Behera B, Jena BL, Behera, Manojit Bhattacharya

Cytosolic Ca 2+ entering the mitochondrial matrix through the mitochondrial Ca 2+ uniporter (MCU) stimulates OXPHOS by activating pyruvate dehydrogenase phosphatase, which in turn, increases the activity of pyruvate dehydrogenase complex [21]

from Sigman et al
