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[DOI] [PMC free article] [PubMed] [Google Scholar] 119.Shimada Y, Hayashi M, Nagasaka Y, Ohno-Iwashita Y & Inomata M Age-associated up-regulation of a negative co-stimulatory receptor PD-1 in mouse CD4+ T cells
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The discovery of these ligands was based on the idea that the activation causes some of the negative side effects of -opioid agonists, as observed in studies in which antagonists blocked morphine-reinforcing behavior [108]
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Gollany, M
Swindell, W
