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Institutional review board statement The animal experiment was approved by The Institutional Animal Care and Use Committee (IACUC) of Beijing Vital River Laboratory Animal Technology Co., Ltd., (No.PA23072602)

Treatment duration critically influences post-discontinuation outcomes with 6-12 month courses creating durable structural improvements supporting ongoing enhanced collagen synthesis without continuous peptide presence, while 2-3 month treatments produce temporary stimulation requiring continuous or cyclical application for maintaining optimal results

Dihexa is an angiotensin IV-derived peptide that acts as a potent HGF/c-Met receptor agonist, stimulating the production of hepatocyte growth factor (HGF), a molecule essential for neuronal repair and growth