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The standard therapeutic strategy for ischemic stroke remains thrombolytic reperfusion therapy provided by intravenous tissue plasminogen activator that is, however, limited by a short therapeutic window of 3-4,5 hours (IST-3 collaborative group et al., 2012

This flare is a recognized phenomenon, not a side effect

Comput Biol Chem 83:107096

Total antioxidant capacity of the diet is associated with lower risk of ischemic stroke in a large Italian cohort

Ox Med Cell Longevity Article ID 8384742

Thus gut microbiota dysbiosis is an important factor causing MDD
