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318 , C174C190 (2020)

A confluence of recent scientific evidence has illuminated how NRF2-driven transcriptional programs support cancer cell survival through tumor-intrinsic mechanisms and also sculpt the tumor immune microenvironment to suppress cytotoxic immune responses and dampen the efficacy of anti-PD1 checkpoint immunotherapy

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& Ersland, L

MTHFR is a key enzyme in folate metabolism