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Key Takeaways Many factors like vitamin B deficiency, drinking and smoking, expired lip products, and hormonal imbalance can cause dark spots on the lips

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The nightly use of sodium oxybate is associated with a reduction in nocturnal sleep disruption: a double-blind, placebo-controlled study in patients with narcolepsy

doi: 10.1080/15374410701818681

Verapamil As a calcium channel blocker used in the treatment of hypertension, verapamil plays an anti-fibrotic role by blocking the transportation of calcium into fibroblasts, inhibiting the transfer of proline into the matrix and stimulating the phenotype transformation of fibroblasts to produce collagenase (Han et al., 2016)

TNF- = tumor necrosis factor-