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Additionally, SIRT3 deacetylates ceramide synthases, promoting ceramide accumulation and inhibiting complex III activity 184

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If orforglipron can be manufactured at scale for a fraction of the cost of injectable alternatives, and if its oral format eliminates the injection barriers that prevent millions from starting therapy, the public health impact could be measured in reduced cardiovascular events, fewer diabetes-related amputations, decreased obesity-related cancer incidence, and extended healthy lifespan across populations