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To minimize variation, mothers who smoked, had diabetes or other pregnancy complications were excluded from the study

Total RNA extraction and RT-qPCR Total RNA was extracted from tissues and cultured cells using the RNAiso Plus reagent (Takara Bio, Tokyo, Japan) in accordance with the manufacturers protocol

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Pathological increases in local concentrations of ROS cause oxidative stress (102)

Without sufficient vitamin B12, this process is impaired, leading to what is referred to as the methylfolate trap

Semin Cancer Biol 75:314 Kim I, Shu CW, Xu W, Shiau CW, Grant D, Vasile S et al (2009) Chemical biology investigation of cell death pathways activated by endoplasmic reticulum stress reveals cytoprotective modulators of ASK1
