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These authors conducted a cohort study using data from the French National Health Insurance Database which included almost 5 million patients initiated on an AD from 2010 to 2015

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However, given the huge variability in the type and composition of probiotics and the lack of validation studies, its use is not routinely recommended for patients with HE

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diagnostic evaluation history Careful review of medication list, focusing on any recent changes (look up drugs individually to determine if they lower seizure threshold, or if they participate in drug-drug interactions with other medications that affect seizure threshold)

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