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It was shown that long-term treatment (72 h) of hippocampal slices with BDNF (250 ng/mL) increases synapse number and spine density at the level of apical dendrites of pyramidal neurons in the hippocampus [35], suggesting that BDNF acts selectively on different types of spines, depending on the level of basal, spontaneous synaptic transmission

doi: 10.1155/2022/9938392 233 ChenLYanYChenTZhangLGaoXDuCet al

Nucleic Acids Res 50:D622D631

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This means KPV enters directly into the cells lining your gut wall, where it can reduce inflammation at the source