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By comparison, oral B12 supplements are absorbed at roughly 1 to 5% in healthy adults, and even less if you have low intrinsic factor, atrophic gastritis, celiac disease, Crohn's, or a history of gastric bypass

If youre following a strict diet program you may be at risk for a B-12 deficiency which may be characterized by fatigue, insomnia, depression, or even heart disease

For example, a meta-analysis found that two copies of the MTHFR C677T variant (A/A, homozygous) increase the relative risk of heart disease by 38%.[ref][ref] However, not all studies agree, and a large prospective study (n=6,000) found that older people with two copies of the C677T allele were at a 30% decreased risk of death from cardiovascular disease when other parameters were included.[ref] The increased risk is not just due to high homocysteine

Side effects may decrease (because the effective dose is lower), giving a false impression that tolerance has developed

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For those who are visual learners, our team and collaborators often break down complex topics and procedures on channels like the MorelliFit YouTube channel, which can be a fantastic supplementary resource