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Diagnosis typically requires: MRI or CT scans to detect inflammation Blood tests that include IgG4 levels A biopsy to confirm the presence of IgG4-positive cells Surveying symptoms from head to toe What is IgG4 in blood tests

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Another approach to modulate NNMT involves bisubstrate inhibitors, which are designed to resemble both the substrate (NAM) and the cofactor (SAM)

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