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Their resistance has been linked to their capacity to reduce ROS levels through the accumulation of intracellular antioxidants like glutathione and the induction of GCL, as demonstrated in breast and liver TICs [18,19,20]

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Mechanistically, molecular docking and surface plasmon resonance assays revealed that isobavachalcone directly binds estrogen receptor (ER), an NLRP3 transcription factor, thus inhibiting NLRP3 transcription and the expression of caspase 1, GSDMD and IL-1 (Wu Y

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[DOI] [PMC free article] [PubMed] [Google Scholar] 18.Paolisso G., Di Maro G., Pizza G., DAmore A., Sgambato S., Tesauro P., Varricchio M., DOnofrio F