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Single nucleotide polymorphism in the gene leading to an Arg 213 His amino acid substitution is relatively frequent in the Caucasian population (25.436.5%) (Glatt & Meinl, 2004)

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Thus, an absence of a change in CBF during increases in blood pressure due to increased resting cerebrovascular resistance in neurodegenerative models may mask differences in autoregulatory function

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Free Radic Biol Med 46 , 16331638, (2009)

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Features of the metabolic syndrome and subclinical atherosclerosis in patients with cerebrotendinous xanthomatosis: an augmented risk for premature cardiovascular disease

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