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NLRP3 inflammasome activates caspase-1 to cleaves pro-IL-1 and pro-IL-18 into the active forms IL-1 and IL-18, meanwhile, cleaves the amino-terminal fragment of the key protein gasdermin D (GSDMD) to form N-GSDMD, which oligomerizes and forms membrane pore formation leading to pyroptosis and subsequent inflammatory response

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[DOI] [PubMed] [Google Scholar] 140.Kumawat BL, Sharma CM, Tripathi G, Ralot T & Dixit S Wilsons disease presenting as isolated obsessive-compulsive disorder

Mechanistically, the overexpression of GPX4 protects cells from apoptosis by detoxifying the oxidative damage of membrane lipids, inhibiting mitochondrial release of CYCS, and inactivating caspase 3 [87]