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Strengths and Limitations of RCTs RCTs are often considered the gold standard for evaluating causal hypotheses, but it is important to clarify what they doand do notdemonstrate

MS-CU (compound 37, Figure 26) showed stronger binding affinity for all tested proteins (MMP-9, MPO, COX-2, and TNF-) compared to mesalamine alone

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All slides were photographed using a Keyence All-in-One Fluorescence Microscope BZ-X 710 (Keyence Corporation, Osaka, Japan) at a magnification of 120 and analyzed per unit area of 10,800 m 2 (120m90m) using a Keyence BZ-X Analyzer 1.4.0.1 (Keyence Corporation, Osaka, Japan)