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The glyoxalase pathway (consisting of glyoxalase I and glyoxalase II enzymes) for detoxification of methylglyoxal, a cytotoxic molecule, also requires GSH in the first reaction step

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Finally, ROS can also lead to lipid peroxidation, whose byproducts can also react with DNA to produce exocyclic DNA lesions (Yu et al., 2016)

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[DOI] [PubMed] [Google Scholar] 62.Toh S.Y., Zarshenas N., Jorgensen J