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A randomised placebo-controlled trial (RCT) including 42 participants with schizophrenia, who were experiencing an acute phase of symptomatology, were randomly assigned to receive up to 2 g/d of NAC plus up to 6 mg/d of risperidone for 8 weeks as an adjunct intervention

[DOI] [PMC free article] [PubMed] [Google Scholar] 29.Pizzorno J

This may be attributed to the dimeric structure which hinders enzyme access to active sites, showcasing significant resistance to enzymatic degradation 49,55

GSH as cysteine storage and the -glutamyl cycle Storage of cysteine is one of the most important functions of GSH because cysteine is extremely unstable extracellularly and rapidly auto-oxidizes to cystine, in a process that produces potentially toxic oxygen free radicals (Meister, 1988)

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